Vol. 7, Issue 1, Part B (2025)

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used for diabetes and obesity but pose challenges during endoscopy due to delayed gastric emptying and increased retained gastric contents. Although aspiration risk remains low in large studies, higher rates of RGC often lead to procedural interruptions. Current guidelines differ, with some supporting individualized fasting and others recommending clear liquid diets or optional drug withholding. This brief communication summarizes evidence, highlights guideline variability, and proposes a practical risk-stratified approach to optimize procedural safety while maintaining metabolic stability in patients using GLP-1 RAs.